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Although this was the only primary effect to attain significance across the whole sample (14 men and 16 women exhibited left frontal WMH), when the regression was rerun for men, it was statistically unreliable.
Nevertheless, the possibility that environmental agents that we have not yet studied or identified have a primary effect to increase ingestive behavior or decrease satiety via central or peripheral mechanisms cannot be eliminated.
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In conclusion, the 825T allele of GNB3 is likely to accelerate the development of DPN through primary effects to SBP and hypertension in subgroups of diabetic patients with impaired neurovascular function and advanced oxidative stress.
The program is enjoying a substantial grant from the Italian Ministry of University and Research and is aimed both to set up novel diagnostic tools capable to detect and decode physical ECM modifications, and to further develop physical means capable to induce ECM modifications as a primary effects to promote therapeutic effects.
17 In all of these studies, statistical power has inevitably been reduced by the processes required to filter out the primary effect attributable to DRB1 and the large correction required for multiple testing.
A non-steroidal selective estrogen receptor modulator (SERM) whose primary effect is to competitively inhibit the binding of estradiol to ERs, tamoxifen prevents the receptor from binding to the estrogen-response element on DNA.
When the sealer is used early and reapplied periodically, the primary effect is to reduce the effective surface chloride concentration.
In this context, the primary effect refers to the ability of an intervention to directly reduce risk of malaria.
Although thiazolidinediones (TZDs) have been shown to improve β-cell function (1– 5), their primary effect is to decrease peripheral insulin resistance (6– 10), while biguanides decrease hepatic glucose output (11).
Thus, the primary effect appears to be a change in the gain of a neuron's response to all stimuli.
Their primary effect is to decrease LDL-cholesterol and total cholesterol; however, they have also been shown to effect benefit by decreasing apolipoproteins B, C-II, C-III and E, and by modestly increasing high-density lipoprotein-cholesterol [ 5], an effect that might be linked to their ability to activate peroxisome-proliferator-activated receptor (PPAR -α.
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