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Although it is unlikely that these small changes in flow are an important primary effect in the development of hypoperfusion, increased metabolic rate with increased CBF may indicate pressure-dependent collateral flow potentially in regions embolized during CPB.
Furthermore, we demonstrate that depletion of Ubx during embryogenesis has a primary effect in T3 legs and causes shortening of leg segments that are enlarged in a wild type.
Also, a primary effect in one cell region with axonal projections to other regions would most likely affect the protein expression in the latter regions.
Thus, the excess of muscle development genes in fat and gonads might simply reflect a pleiotropic change caused by a primary effect in muscle.
While this may be an off-target mechanism relative to the approved indication for the test agents, reduction in fibrosis is primary effect in the context of FSGS.
Just as it proved difficult to establish that DRB1* 1501 is responsible for the primary effect in this region, it may prove even more difficult to refine this secondary effect in detail.
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These primary effects in turn affect donor innovation, information hoarding, and aid disbursement volatility, as well as recipient country health budget levels, human resource capacity, and corruption, and the determinants of health program performance.
In order to examine primary effects in more detail, a sensitivity study based on numerically generated TRT data sets is performed considering the effects of (1) the in-situ position of the U-shaped pipes of borehole heat exchangers (shank spacing), (2) a non-uniform initial thermal distribution (such as a geothermal gradient), and (3) thermal dispersivity.
We know that those biological changes have primary effects in the brain especially in the areas responsible for governing judgment, inhibition, motivation and learning.
These primary effects in blood in turn were propagated into the interstitium through permeability, i.e., via reduced net sVEGFR1 extravasation and upregulated net VEGF intravasation.
These recurring patterns of ocean-atmosphere variability have very different behaviors in time; ENSO events persist for 6 18 months and have major impacts in the tropics whereas the PDO occurs over a much longer time frame of 20 30 years and has primary effects in the northern Pacific (Mantua and others 1997).
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