Sentence examples for primary downstream mediator from inspiring English sources

Activated AKT, also known as protein kinase B, is induced by phosphoinositide 3-kinase (PI3K) and represents the primary downstream mediator of the metabolic effects of insulin [ 15].

Thus we can speculate that central NPY pathways, e.g. centrally NPY receptor activation, are the primary downstream mediator of circulating ghrelin.

Two main downstream mediators of cAMP are protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac).

We therefore hypothesize that one or more of the HES/HEY family of repressive bHLH transcription factors, some of the primary downstream targets of RBPjk-dependent Notch signaling, act as mediators of Notch signaling to repress Sox9 gene expression.

It probably suggests that NF-kB is a downstream mediator of the GSK-3 signaling cascade.

JNK is frequently a downstream mediator of TKR responses.

These results clearly implied that TG2 is a downstream mediator of TGF-β-induced EMT.

Similarly, the downstream mediator MyD88 [46], [46] was decreased at the protein level (Figure 4B).

Collectively, these studies demonstrate that ATF4 is a novel downstream mediator of PTH signaling.

We further show that a downstream mediator of this integration is the Shh signaling pathway.

Conversely, Serum- and Glucocorticoid regulated Kinase-1 (SGK1), a downstream mediator of aldosterone, increases ENaC activity.