Sentence examples for primary downstream effector from inspiring English sources

Since AC is the primary downstream effector of Gαs, and since CRFR1 couples to Gαs in striatal neurons (Figure 6), we wondered why we failed to observe CRF-induced cAMP accumulation (Figure 3).

4E-BP1, the suppressor of eIF4E, has been widely recognised as the other primary downstream effector of mTOR.

These proteins are key components of the IL-1 and Toll-like receptor signaling system, of which NFкB activation is a primary downstream effector.

PKA is the primary downstream effector of cAMP, regulating neurotransmitter release through activation of Ca2+ channels or inactivation of K+ channels [ 3, 4].

Phosphorylated (p- AKT, the p- AKTy downstheam effector of primarygnaling, moves from the cytoplasm to the nucleus to initiate its downstream effector

In addition, the concept that NAGly acts as an agonist for GPR18 was further challenged recently when it was found that, in GPR18-expressing rat sympathetic neurons, NAGly failed to induce any GPR18-mediated inhibition of N-type (Cav2.2) channelannel, a primary downstream effector of Gi/o (Lu et al., 2013).

The two primary downstream effectors of GLP-1R-induced cAMP are protein kinase A (PKA) and the cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF), Epac.

In fact, our microarray analysis demonstrated that STAT6 appears to have non-identical target genes in two different GBM cell lines, suggesting that even among Grade IV/GBM tumors, its primary downstream effectors may differ considerably.

In contrast, our work across the NCI60 cell lines and three primary cancers has focused on miRNA downstream effector genes without considering target prediction, and hence, effectively avoids the highly false positive rate produced by target prediction algorithms.

Both this study and our previous investigations showed that pS6, the best-characterized downstream effector of mTORC1, is upregulated in primary renal tumors with metastasis [ 16, 17], indicating that pS6 might influence the progression of RCC.

The bactericidal mode of action of antibiotics has recently been shown to depend less on their primary target, and more on the induction of common downstream effector mechanisms leading to cell death.