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It uses social channels as its primary discovery mechanism, but it also allows users to give back, with all the usual social sharing tools — posting to Facebook or sending video recommendations by email or SMS.
Their replication outside of the primary discovery cohort gives added reassurance that these may be true positive hits.
However, without subsequent verification of primary discovery findings through accurate quantitative assays, the results obtained from such analyses are supported only by restricted significance.
This clinical sample was selected as the primary discovery sample because it is similar to the ALSPAC general population in ethnicity and underwent similar diagnostic assessment procedures.
As a primary discovery approach, screening across unabridged test results poses large statistical penalties for multiple tests eroding confidence in associations that fail to achieve genome-wide significance [ 2, 13- 18, 21].
One possible advantage of the primary discovery ADHD sample used to derive risk alleles, over the replication sample, is its similarity to the ALSPAC cohort in terms of ancestry and geography, but nevertheless the sample was relatively small (4).
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Two primary discoveries of the present investigation are (1) Gr/Si superlattice exhibits significantly stronger interlayer bonding than graphite, and (2) the electronic band structure near the grapheme K point is practically unperturbed by the Si layer, but with significant electron transfer from the Si layer into the graphene layer.
One of the primary discoveries to come from studies of transgenic polyglutamine toxicity, as well as the other proteotoxicity models, in C. elegans is that the same genetic and environmental features that modulate aging also modulate resistance to proteotoxic stress.
From a standpoint of statistical significance, studying inherited disease at the genomic level requires large numbers (ideally thousands) of cases (affected) versus controls (unaffected) to uncover initial findings, as well as the replication of any primary discoveries in other case-control cohorts to solidify the association of a given genomic variant(s) with disease.
This growth is accelerating and the role of these platforms as primary content discovery and viewing environments will reach a point by the end of the year that they will soon be as large and important as Google search.
First, our primary biomarker discovery and prediction model training were performed by contrasting familial hypercholesterolemia patients against healthy controls.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com