Sentence examples for primary defects that from inspiring English sources

To identify the primary defects that underlie the etiology of the disease, we therefore investigated wound healing in Pax6+/- corneal epithelial primary culture.

Comparison of the primary defects that arise across various mutants will help to group them into biochemical pathways controlling specific cellular processes.

Insulin resistance and impaired beta-cell function are primary defects that occur early in the course of development of type 2 diabetes.

The study further indicates that impaired chemotaxis of neutrophils is the primary defect that leads to an increased susceptibility to pulmonary aspergillosis in transplantation.

The primary defect that leads to preeclampsia indeed involves alteration in the dialogue between invasive placental trophoblast cells and maternal immune cells in the uterine wall.

Although β-cell failure is the sine qua non for development of type 2 diabetes, skeletal muscle insulin resistance is considered to be the initiating or primary defect that is evident decades before β-cell failure and overt hyperglycemia develops (3, 4).

Thus, the presence of clones of small cells within the plane of the normal wing blade may be a primary defect that contributes to the observed phenotypes.

It is very likely that the primary defect that caused a lowered insulin signaling level in tomm-40 RNAi) tomm-40 RNAianimalsase in DAF-28 secretion because overexpression of DAF-28 in daf-16::gfp; tomm-40(RNAi) animals rescued the nuclear localization of daf-16::gfp (Figure 6G).

However, there are two primary design defects that are inadequately addressed: accuracy and ergonomics.

Furthermore, some of the observed defects might be secondary to other abnormalities and not primary defects, possibilities that can only be investigated using tissue-specific conditional mutants.

The first hypothesis, based on the aberrant abdominal and umbilical vascular pattern of affected individuals, postulates a primary vascular defect that leaves the caudal part of the embryo hypoperfused.