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Further studies should investigate whether the defective PGC-1α expression is a primary defect or whether it is secondary to insulin resistance or reversible lipotoxicity.
The primary defect lies in the growth zone of the long bones.
Congenital sucrase-isomaltase deficiency (CSID) is a genetically determined primary defect of SI which is associated with carbohydrate malabsorption [3].
Accidental hypothermia concerns a body core temperature of less than 35 °C without a primary defect in the thermoregulatory system.
Dynamic Monte Carlo simulations of primary defect aggregation in tracks of swift heavy ions in alkali halides have been performed.
It appears that the primary defect in the disorder may have occurred in the embryological development of the lower leg [4, 6].
This suggests that a primary defect in CFTR expression is not the root cause of neutrophilic inflammation in these disease contexts.
A primary defect of steroidogenesis resulting in increased ovarian and adrenal androgen production may be responsible for polycystic ovary syndrome, at least in some patients.
The flap is asymmetrical, thus enabling transposition of more tissue into the primary defect than is lost from the donor site.
The literature on PWS has long suspected that the primary defect lies in hypothalamic dysfunction.
Third, Snord116del mice may have a primary defect in another brain region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com