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Theoretically, a primary decrease in bone formation and decreased buffering capacity for calcium, with consequent increased urinary expression of dietary calcium could account for the relationship between osteopenia and hypercalciuria in GPRC6A−/− mice.
IMAT can be present in conditions characterized by an increase in muscle mass, such as in acromegaly [48], but it is particularly evident in conditions characterized by a primary decrease in the muscle mass as in myopaties, aging [49], and sedentary young subjects.
Alternatively, increased hematocrit levels and, therefore, increased viscosity may be a compensatory response to a primary decrease in oxidative capacity.
Reduced serum concentrations of IGFBP-3 can result from a primary decrease in IGFBP-3 production, or secondarily, due to a reduction in IGF-I.
We recently documented a primary decrease in peripheral impedance and an increase in peripheral compliance associated with a decrease in central aortic compliance in a porcine model of early endotoxic shock [ 10].
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These responses are often characterized by primary decreases in important indices of cardiac and thermoregulatory function, along with secondary decreases in associated parameters.
There was no significant change in the primary variable peak decrease in mPAP from baseline up to 6 h after study drug administration—in the riociguat 2 mg group vs placebo group (P =.6) (Figs 2, 3, e-Table 1).
Use of VA primary care decreased in both groups over time, while use of Medicare primary care services increased over time.
In mediterranean-climate streams, environmental factors are particularly strong, as regular summer droughts results in flow reductions, changes in primary productivity, decreases in dissolved oxygen, and increases in conductivity over the course of the season (Gasith and Resh 1999).
Changes in these vessels can support a more primary role of decrease in blood flow in the development of AMD, although a secondary autoregulatory response to a primary change elsewhere can not be ruled out (Ciulla et al 1999).
Primary endpoint was decrease in number of headache days at 6 weeks, relative to baseline, comparing both groups.
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