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For most reviews, Woodman et al could explain why primary data were not included, which was usually due to the reviews having a relatively narrow scope.
In all, 4 of the 20 chemotherapy studies could not be included in the patient-level analysis as primary data were not available (Osterborg et al, 2005; Engert, 2007; Strauss et al, 2008; Aapro et al, 2008a).
Where primary data were not available, formulae to use P values/frequency tables to estimate d were used based on the Campbell Collaboration free online effect size calculator (available online at http://www.campbellcollaboration.org/escalc/html/EffectSizeCalculator-SMD2.php, accessed 9th September 2014).
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Since these data come from the time period after our fieldwork was conducted cross checking with primary data is not possible.
Because of both dataset size and health data security, primary data is not made available through the web.
The sample prevalence as quantified on the basis of the available primary data was not varied in the scenario analysis because there were no conflicting data.
All too often primary data are not available for reanalysis either, reflecting a lack of enforcement of editorial policies, or the absence thereof in some journals.
Furthermore, certain ancillary study data management scenarios (such as populating an ancillary study with primary data) are not typically required for the completion of a primary clinical trial or study, so they may not be supported.
Whereas character-state data (e.g., nucleotide sequences) are commonly used for parsimony, maximum likelihood or Bayesian analyses, distance methods can be selected as an alternative option to decrease computing time when analysing large data sets, or else, can be used in comparative studies where the primary data are not available.
Reston and Turkelson[ 28] pointed out that their study is an explicit attempt to provide a conclusion when reliable primary data are not available and recognized that clinical and policy decisions must often be made in the absence of well-designed trials.
For the primary efficacy analysis, missing data were not imputed.
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