Sentence examples for primary cellular response from inspiring English sources

While NAS affects only the splicing process, nonsense-mediated mRNA decay (NMD), the primary cellular response to mRNA carrying a premature termination codon (PTC), rapidly degrades fully spliced transcripts.

It is known that base excision repair pathways are the primary cellular response to alkylation damage [1], [28], [29], [30], [31], [32], though Y family DNA polymerases are also part of this response [1], [19], [20], [21].

The pan-caspase inhibitor Z-VAD did not block MDMX destabilization (whereas the proteasome inhibitor ALLN did), indicating that 17AAG-induced MDMX destruction was a primary cellular response, rather than simply a secondary caspase-mediated degradation event.

The pan-caspase inhibitor Z-VAD did not block MDMX destabilization, indicating that MDMX degradation by 17AAG was a primary cellular response rather than a secondary caspase-mediated degradation event.

While our results highlight that the primary cellular response is an anti-proliferative response (as opposed to an apoptotic response), for the development of ETP-45658 as a potential therapeutic, we questioned if ETP-45658 exposure was associated with any degree of toxicity, one of the most fundamental questions for any proposed therapeutic.

Given the extremely complex nature of cellular signal transduction networks in spatio-temporal dimensions, any observed effect could be secondary, adaptive, driven by negative or positive feedback-loops and thus far beyond the initial and primary cellular response to altered gravity.

First, GSH is a protagonist of the primary cellular responses to As III).

The primary cellular responses to hypoxia are generally mediated by the transcription factor hypoxia-inducible factor 1 (HIF-1).

The primary cellular responses to oxygen deprivation (hypoxia) are mainly mediated by the transcription factor hypoxia-inducible factor 1 (HIF-1).

Relative transcriptional analyses of yeast ABC transporters clearly demonstrated that one of the primary cellular responses caused by de novo artemisinic acid synthesis in engineered yeast is rapid transcriptional activation of various ABC transporters.

GO analysis showed that the targets of aberrant miRNA took part in many biological processes, such as primary metabolism, cellular response to stress, negative regulation of transcription, DNA-dependent, and regulation of endocrine process.