Our data provide a platform to evaluate molecular pathways or primary cellular targets of compounds for further development of antitumor agents.
It is known that base excision repair pathways are the primary cellular response to alkylation damage [1], [28], [29], [30], [31], [32], though Y family DNA polymerases are also part of this response [1], [19], [20], [21].
Again, the effects of IDN 5390 and PTX on pathways involving Bcl-2 and Raf phosphorylation were comparable, thus suggesting a common mechanism of action at the cellular level, with tubulin as the primary cellular target and activation of biochemical pathways that typically characterise the cellular response to microtubule damage (Cassinelli et al, 2001; Lanzi et al, 2001).
TF is a 47-kDa transmembrane glycoprotein that serves as the primary cellular initiator of the extrinsic coagulation pathway by acting as a ligand for factor VII/VIIa and ultimately activating factor × (reviewed in [ 45]).
We first created a more complete picture of cellular pathways that impact mutation rate using a primary screen to identify essential Saccharomyces cerevisiae gene mutations that cause mutator phenotypes.
The integrative analysis combining miRNA expression, mRNA expression and the related cellular pathways revealed that the majority of radiochemotherapy-responsive pathways in primary HNSCC cells are related to cell cycle, proliferation, cell death and stress response (including inflammation).
The primary function of this protein remains unknown; however, Btn1p has been implicated in several cellular pathways.
As a model for the reactive cellular pathways that may be controlled by Pax6, we have developed an in vitro wounding assay for murine primary corneal epithelial cells and have investigated the roles of Pax6 in corneal healing.
First, we identified significant global changes across multiple cellular pathways.
Benign cellular pathways are complex, malignant ones more so [9].
