Sentence examples for primary cell death from inspiring English sources

The company behind the study, eGenesis, which was founded by Harvard genome godfather George Church and Luhan Yang, says it used a technique involving a combination of CRISPR and a method preventing primary cell death during the editing process to inactivate all 62 copies of PERV in piglet embryos.

Collectively, these results suggest that As2O3-induced autophagy confers a protective role against apoptosis which is the primary cell death mechanism induced by As2O3.

During the acute hypoxic-ischaemic insult, some cells undergo primary cell death, the magnitude of which will depend on the severity and duration of HI.

While apoptosis is clearly a primary cell death mechanism, there is much controversy about the functional role of autophagy in life and death.

Although the circumstances under which autophagy functions as a primary cell death mechanism or survival remain to be defined, it is hypothesized that autophagy inhibition promotes apoptosis in cancer cells with intact apoptotic signaling pathways.

We demonstrated through PI/AV assessment that SIM+MET treatment led to significant increase in PI C4-2B cells by 48−96 h; in fact, at the 96-h combination treatment, 61−64% of C4-2B cells were either PI/AV or PI/AV, strongly implicating necrosis as the primary cell death process associated with SIM+MET treatment in C4-2B cells.

Nevertheless, combined treatment enhanced primary GBM cell death when compared with TMZ alone.

We then directly tested whether autophagy inhibition alone induced primary schwannoma cell death.

There are two primary programmed cell death signaling pathways [ 2], apoptosis [ 3] and autophagy [ 4], of which apoptosis has been researched more extensively.

We note that primary HR cell death is also similarly suppressed in older atg mutants, and that we observe no marked differences among genotypes if ion leakage measurements are extended to 12 h (data not shown).

Hess (1965) showed that the increase in oxidative stress caused by low RH rather than dehydration alone was the primary cause of cell death.