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Depending on a biofilm lifestyle, Streptococcus mutans (S. mutans) is thought to be one of the primary causative agents of dental caries.
In Brazil, two viruses are the primary causative agents of epizootic diseases of Litopenaeus vannamei farmed in the northeast of Brazil: infectious hypodermal and hematopoietic necrosis virus (IHHNV) and infectious myonecrosis virus (IMNV).
These two factors, plus the requirements for primary causative agents [12] at elevated concentrations and for susceptible target Symbiodinium types, may all contribute to facilitating WS epizootics.
Thus we conclude that, although all WS pathogens identified possess a zinc-metalloprotease gene sufficient to cause rapid photoinactivation and coral tissue lesions, not all Vibrio strains possessing this gene can be classified as primary causative agents of WS.
These signs, which were expressed by coral juveniles in response to bacterial supernatants, were identical to WS disease signs observed on adult corals in the field [84] [85] and during pathogen inoculation experiments [12], and further support our previous findings, which identified Vibrio pathogens as the primary causative agents of WS's [12].
These newly emerging coral diseases, either caused or associated with members of the Vibrionacae family have sparked a debate on the origin of Vibrio pathogens and their role in the aetiology of coral diseases: Are Vibrio pathogens the primary causative agents of all these diseases?
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The fungus Aspergillus fumigatus (A. fumigatus) is the primary causative agent of invasive aspergillosis.
Avian metapneumovirus (AMPV) is the primary causative agent of severe rhinotracheitis in turkeys.
PCV2 is the primary causative agent of a group of diseases called porcine circovirus disease (PCVD) in swine.
This is also due to the emergence of antibiotic-resistant strains (MDR-TB and XDR-TB) of the primary causative agent Mycobacterium tuberculosis (MTB).
Mannheimia(Pasteurella)haemolytica serotype 1 is the primary causative agent responsible for bovine pneumonic mannheimiosis, also known as shipping fever in cattle.
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