Sentence examples for primary binding sites from inspiring English sources

The lead compound 1a was originally found in our factor Xa (fXa) inhibitor library on the basis of structural similarity of the primary binding sites of fVIIa and fXa.

The two primary binding sites (site I and site II) are hydrophobic cavities located in subdomains IIA and IIIA, respectively.

Amongst the P2Y receptors, P2Y1, P2Y12 and P2Y13 are the primary binding sites for ADP (von Kugelgen, 2006).

This observation seems to imply that ZFa ZF4, like JAZ ZF4, is not one of the primary binding sites for dsRNA.

Higher loadings at 80 K did not show any additional well defined CD4 molecules, but the primary binding sites remained occupied.

The mechanism is an emergent property of the transposition reaction, based on the competition of active transposase multimers for their primary binding sites at the transposon ends.

This observation is consistent with the fact that the primary binding site in GalMBP binds galactose and not fucose (Iobst and Drickamer 1994), so although both native MBP and GalMBP can bind the Lewisx structure, they must do so in very different ways, with fucose in the primary binding site of MBP and galactose in the primary binding site of GalMBP.

Structural and mutagenesis studies indicate that GalNAc and galactose bind in the primary binding site on the CRD, ligated to the binding site calcium ion and packing against a tryptophan residue for increased affinity and specificity, with further selectivity for GalNAc resulting from favorable contacts with the 2-acetamido group (Iobst and Drickamer 1996; Kolatkar et al. 1998).

These are delineated as outward-facing and inward-facing, respectively, and when the extracellular substrate binds to its primary binding site termed S1, alongside Na+ and Cl−, this results in a conformational change from outward-facing to inward-facing (Yamashita et al., 2005; Kniazeff et al., 2008; Shan et al., 2011).

Binding and activation of the C5aR by C5a is considered a two-step process, in which residues in the region between 12 and 46 of C5a bind to a primary binding site located in the extra-cellular N terminus of the C5aR.

The individual mutations result in decreased affinity for trehalose compared with the affinity for α-methyl glucoside, which can only bind at the primary binding site, and the double mutant is reduced to an affinity only twice that of methyl glucoside, corresponding to the fact that there are two glucose residues in the trehalose molecule.