Sentence examples for primary activators of from inspiring English sources

The primary activators of jasmonic acid-mediated signaling are bHLH-type transcription factors that are conserved between Arabidopsis and rice.

Although expression of endogenous Wnt target genes has been shown for primary activators of the Wnt pathway [2], no significant changes could be detected for LRP6-ICD or AES (data not shown).

We therefore propose that Crx and Nrl are the primary activators of gene expression for the majority of rod genes in the mouse, and that other TFs expressed in rods such as Nr2e3 and Neurod1 are involved in fine-tuning expression.

It was traditionally thought that the contact factors, factor XII, factor XI, prekallikrein, and high-molecular-weight kininogen were the primary activators of the clotting cascade in sepsis.

For instance, lymphoid resident CD8+ DCs are considered the primary activators of CD8 T cells, via cross-presentation [ 38], and DCs that migrate from the skin have shown a preference to activate CD4 T cells [ 39].

This primed state is reflected at the chromatin level by a general lack of the repressing H3K27me3 across the QSC genome and the presence of H3K4me3 at the TSSs of a large number of genes, including the myogenic regulatory factors, Myf5 and MyoD, whose protein products are the primary activators of the myogenic program.

It indicated that genome structural changes might activate the primary activator of the gad system but fairly influenced the global transcriptional factor (sigma factor).

Phosphorylation of S6K1 on Thr390 (human Thr389) is a primary activator of its kinase activity and appears to regulate translation of ribosome-related transcripts and ribosome biogenesis, although the mechanism underlying differential regulation of phosphorylation of Eif4ebp1 and S6K1 by Frap1 is currently unknown [31].

Historically, GLI1 has been considered the most reliable marker of HH pathway activity, however GLI2 appears to be the primary activator of HH signaling, with GLI1 as a transcriptional target of GLI2 [7], [7], leading to augmentation of HH signaling both quantitatively as well as qualitatively [16].

Recent evidence suggests that the primary activator of the channels is likely to be a lipid messenger derived from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by PLC.

Menthol is also a primary activator of the cold- and menthol-sensitive TRPM8 channels [11], [12].