Sentence examples for primary activating from inspiring English sources

The structural insights obtained from the present analyses, together with our previously published kinetics data, suggest that TR, and by inference, wild-type eEF-2K, upon engaging CaM undergoes a conformational transition resulting in a state that is primed to efficiently auto-phosphorylate on the primary activating T348 en route to full activation.

In addition, primary activating cues following wounding probably involve growth factors and/or mechanical signals that have yet to be defined.

In bony fish, novel immune type receptors (NITRs) which contain an N terminal variable domain and a C terminal Ig domain have been identified as the primary activating and inhibitory receptors expressed by NK cells [ 53].

17, 18 Unlike GISTs, the common primary activating mutations in the context of SM, AML, and germ cell tumors are located in the KIT kinase activation loop, such as D816H/V/Y and N822K, and some have been shown to confer imatinib resistance in vitro and/or in vivo.

However, this role appears to be a minor one relative to the presumed primary activating role implicit in the model used to construct the computational search.

From the concepts reviewed, outsourcing strategies of SMEs can be measured in terms of outsourcing of back office activates, primary activities, accounting activities and support activities (Gilley and Rasheed, 2000; Isaksson and Lantz, 2015).

It indicated that genome structural changes might activate the primary activator of the gad system but fairly influenced the global transcriptional factor (sigma factor).

A primary pathway activating mTOR signaling involves PI3K-dependent growth factor signaling and both EBV and KSHV up-regulate the PI3K/Akt signaling pathway leading to mTOR activation [21], [44] [47].

For example, the interaction between the sensor Wsc1p and the Rho1p GEF Rom2p is the primary step activating the CWI pathway (Philip and Levin 2001).

While the phenotype of primary HSC activated in culture typically models the phenotype of HSC activated in the liver in response to fibrotic insult, it is critical to validate results of cell culture experiments with data from HSC activated in vivo.

It is noteworthy that primary rat activated microglia are more prone to trigger necroptosis than mouse activated microglia to TLR3/4 stimulation and caspase inhibition [ 27].