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Before the Incarnation, civil ownership and civil use were grounded in man-made laws designed primarily to regulate property ownership.
We showed recently that Irgm1, as well as its close relatives, Irgm2 and Irgm3, function primarily to regulate the activation of other "effector" members of the IRG protein family such as Irga6, Irgb6 and Irgd [8].
About half of 'Alternative' adolescents' self-injure, primarily to regulate emotions and communicate distress.
One interesting possibility is that CD4+CD25+ Treg cells serve primarily to regulate naive T cell priming in the secondary lymphoid organs, whereas Tr1 cells serve to dampen effector T cell responses in the periphery.
In contrast, vascular endothelial growth factor (VEGF), particularly VEGF-A, signals through the RTK VEGFR2, primarily to regulate endothelial cell activities that facilitate vasculogenesis, angiogenesis and vascular function (Carmeliet and Jain, 2011, Ellis and Hicklin, 2008, Ferrara et al., 2003).
We speculate that the Hippo pathway originated primarily to regulate cell adhesion and to control body size in Porifera and Placozoa, and with the addition of more functional domains, upstream regulators, and downstream partners, it acquired control over tissue and organ size during Bilaterian evolution.
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Thus, to determine when e.g., a bound protein primarily serves to regulate or primarily serves to prevent degradation seems hard, in particular if preventing degradation is part of the regulatory mechanisms as is the case with the iron metabolism in vertebrates [ 61].
Transcription factor E2F is primarily considered to regulate the G1/S transition of the cell cycle but its involvement in the regulation of mitosis has also been recently suggested.
The first version of India's Information Technology Act, which was enacted in 2000, was primarily meant to regulate electronic commerce, Mr. Duggal explained.
Nephrocytes primarily function to regulate haemolymph composition by filtration and filtrate endocytosis.
Notch is a fundamental signalling pathway in many mammalian cell types undergoing differentiation, primarily acting to regulate cell fate determination.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com