The underlying data shows that each of the NFE2L2 mutation sites in endometrial cancer is also a mutation site in a variety of other cancers, primarily in squamous cell carcinomas.
To evaluate the prognostic potential of the AZGP1, BTG2, CBX2, CNTNAP2, DNALI1, LOC389033, NME5, PIP, S100A8, SCUBE2, SERPINA11, STC2, SUSD3, STK32B, UBE2C, and WHSC1L1 genes in OSCC specimens, three patient cohorts were compiled primarily from squamous cell carcinomas of the oral cavity.
One of the most concerning side effects is the development of cutaneous malignancies, primarily well-differentiated squamous cell carcinomas (SCC) and keratoacanthomas (KA), which occur in up to 25% of vemurafenib users [ 13].
Although tobacco smoking has been shown to be a potential risk factor for both, a link between tobacco smoking and alcohol intake has been observed to be primarily associated with squamous cell carcinoma (IARC, 2004).
Unlike small cell carcinoma, which primarily expresses α7 nAChR, squamous cell carcinoma, adenocarcinoma, and benign bronchial and small airway epithelial cells express multiple nAChR subtypes [21], [27], [32], [33].
For the present study, data were only available for all NMSC combined, potentially diluting the observed effect if it is actually primarily – or only – on squamous cell carcinoma risk.
Squamous cell carcinomas primarily involved the skin, and neoplastic epithelial cells were locally invasive.
Small cell lung cancer accounts for about 15% of all lung cancer diagnoses whereas non-small cell lung cancer constitutes the majority of cases, primarily including adenocarcinoma (AC) and squamous cell carcinoma.
It is primarily composed of two histologic types, squamous cell carcinoma (SCC) and adenocarcinoma (ADC), each apparently having a distinct aetiology (Holmes and Vaughan, 2007).
They sought to determine the incidence and clinical implications of biologically relevant HPV16 infection in a cohort of 107 patients with oropharyngeal squamous cell cancers treated primarily with RT or surgery followed by postoperative RT at Yale University [ 5].
