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In the last 10 years, premature (younger than 75 years) mortality rates have fallen by around 45%. 4 This reflects both improvements in cardiovascular risk factor profiles (primarily reductions in smoking) and advancements in treatment.
It has been documented that a progressive decline in VO2max with age seems to be due to both central and peripheral adaptations, primarily reductions in maximal heart rate and lean body mass [ 42].
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Primarily, reduction of BP is more important than the agent used to reach that goal.
Rather, inhibition of oxidative stress, primarily reduction of gp-91phox, may play an important role in this process.
Planning a population-level breast cancer screening programme can require multiple criteria for decision making; it involves primarily reduction in BC mortality rates, but it also needs to minimize overdiagnosis and false positive events.
The NICE guidance gives more weight to the health economic arguments that are driven primarily by reductions in HbA1c as opposed to reductions in rates of hypoglycaemia.
Harm reduction has focused primarily on reduction of high-risk substance using behaviors rather than reductions in high-risk sexual behaviors.
This was achieved primarily through reductions in contractors and administrative expenses.
Dramatic increases in the rates of chemical transformation by enzymes, compared with the uncatalyzed reactions in solution, result primarily from reductions in activation barriers within enzyme active sites.
These findings also imply that the effects of AGS mutations in ADAR1 are mediated particularly through ADAR1p150 and primarily involve reductions in RNA-editing activity.
Such adherence-based savings in medical costs are driven primarily by reductions in hospitalization rates at higher levels of medication adherence [ 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com