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The structures revealed that the RVR and RR variants primarily recognize the PAM-complementary nucleotides via the substituted residues.
Currently, there are two documented examples of these enzymes in eukaryotic cells: tyrosyl-DNA phosphodiesterase 1 and tyrosyl-DNA phosphodiesterase 2 (formerly TTRAP), which primarily recognize and cleave 3' and 5' tyrosyl-DNA phosphodiester bonds, respectively [13], [14], [15], [16].
To date, there have been two identified tyrosyl-DNA phosphodiesterases in eukaryotes: tyrosyl-DNA phosphodiesterase 1 (Tdp1) and tyrosyl-DNA phosphodiesterase 2 (formerly TTRAP), which primarily recognize and cleave 3' and 5' tyrosyl-DNA phosphodiester bonds, respectively [13], [14], [15], [16].
The structure indicates that SLBP and 3′hExo primarily recognize the shape, rather than the sequence, of the SL.
These data show that the antibodies primarily recognize epitopes in the correctly folded fibrillin-1 molecule but not in the denatured fibrillin-1 molecule.
The antibodies that primarily recognize basal epithelial cells and luminal secretory cells (CD104 and CD26 respectively) show some staining of endothelial cells [ 8].
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TLR-4 primarily recognizes lipopolysaccharide (LPS) a component of the gram-negative cell wall.
Many invasive plant species in Europe are primarily recognized as agricultural or forestry weeds.
MCs are primarily recognized as the key cells in immediate or type 1 hypersensitivity reactions and/or delayed type immune disorders.
A group of interesting molecules called defensins exhibit multiple functions but have been primarily recognized to possess a broad spectrum of antimicrobial activities.
Not surprisingly, CDPKs were primarily recognized as signaling mediators, which perceive rapid intracellular changes of Ca2+ ion concentration, for example triggered by environmental stress cues, and relay them into specific phosphorylation events to induce further downstream stress responses.
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