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Setting mitosis aside, we hypothesized that OCM relies primarily on cell movements.
Previous efforts have focused primarily on cell cycle regulators, but the clinical utility of currently available markers remains limited.
Large-scale phosphoproteomic analysis is a recently developed technology and it is focused primarily on cell growth-related proteomics.
While chemotherapy and IR depend primarily on cell cycle control and p21, heat shock depends primarily on Bax.
Although these mutations are assumed to impact primarily on cell cycle regulation, RB1 has many additional roles, including regulation of chromosome stability, senescence and cellular differentiation (Indovina et al, 2013).
Since many of the conditions applied in this study also resulted in cell death, we made the decision to focus primarily on cell counts, qRT-PCR and, where applicable, flow cytometry.
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In our further analysis we focused primarily on cell-substrate and cell-cell adhesion and on cell motility as these are aspects in which mammalian cytohesins play a prominent role.
This small secreted dimeric protein, originally identified by its ability to promote neurite out-growth, exerts its biological actions primarily on cells of the nervous system [1].
In addition, traditional sampling using RDD methods has faced increasing challenges as more households rely primarily on cell-phones [ 11, 12].
The P2X7 receptors are expressed primarily on cells of hemopoietic origin, where they participate in immune responses, cell proliferation, cell death, bone formation, and bone resorption [ 10].
Syndecan-2 is present primarily on cells of mesenchymal origin [ 8], syndecan-3 is primarily expressed by neuronal tissue and cartilage [ 9, 10], and syndecan-4 is ubiquitously found in most tissues [ 11, 12].
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