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Bone is a composite, living tissue made primarily of type I collagen fibers impregnated with crystals of calcium phosphate.
Immunohistochemistry at 12 and 24 weeks demonstrated an ECM in both hydrogels comprised primarily of Type II collagen, with Types I and Type X collagen also present (Figure 6A, B). Biochemical analyses indicated similar cellularity in both hydrogels and an extracellular matrix comprised of proteoglycans and collagens (Figure 7A, B, C).
This secondary vitreous is essentially extracellular matrix consisting primarily of type 2 collagen [ 2].
The remaining ITS2 copies appeared to be primarily of type C109, since this was the only other sequence detected in the DGGE analysis.
This is significant as the basement membrane is made up primarily of type IV collagen [ 131], although it also contains laminins, osteonectin, heparin proteoglycans, and enactin [ 126, 132].
Fibrous connective tissues, such as ligament and tendon, are composed primarily of type I collagen with type III collagen levels increased during healing [ 41].
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In support of this, the cort-HFD-treated animals in this study showed a significant reduction in epitrochlearis (primarily composed of type II fibers) but not in soleus (primarily type I) muscle mass, suggesting that this treatment attenuates growth primarily in glycolytic muscle fibers.
Li and Zhang [95] reported that they successfully used Chitosan- and alginate-based nanofibrous matrices to mimic the ECM of articular cartilage that primarily consists of type II collagen and proteoglycans (glycosaminoglycan, GAG).
Cartilage is primarily composed of type II collagen and proteoglycan, which are synthesized by the chondrocytes.
This matrix is primarily composed of type II collagen and aggrecans [ 54].
Cartilage of the craniofacial region primarily consists of type II collagen and is derived from cranial neural crest cells that differentiate into chondrocytes.
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