The vesicle-mediated transport is primarily mediated through caveolin based vesicles ([ 19] for review).
This effect was primarily mediated through P-induced amphiregulin (AREG) via a progesterone receptor (PR -mediated mechanism, and AREG exPR -mediated increased by P in both ducts and EBs.
Key mediators of signaling pathways in breast cancer involve post-translational protein modification, primarily mediated through phosphorylation and ubiquitination.
Cytolytic activity of T cells is primarily mediated through the Fas Fas ligand and perforin granzyme pathways.
This effect was primarily mediated through an increase in cesarean delivery carried out for cephalopelvic disproportion/failure to progress.
While BAF complexes contain many such domains, none of these domains has been shown to affect BAF complex targeting, which is primarily mediated through TFs48,49,50.
The effects of vasoactive intestinal peptide (VIP) are primarily mediated through VPAC1 and VPAC2, receptors that are preferentially coupled to adenylate cyclase activation.
Down-regulation in net CO2 fixation (Pn) was primarily mediated through stomatal limitation which concurrently reduced transpiration rate (E), stomatal conductance (gs) and intercellular CO2 concentration (Ci).
These results suggest that the hypotensive effect of AM is primarily mediated through the CLR/RAMP1 heterodimer, but that AM signaling via CLR/RAMP2 and CLR/RAMP3 also contributes to some hypotensive action.
Thus, it seems conceivable that the effect of PACAP38 on mast cell degranulation is primarily mediated through the PAC1 receptor because VIP had a lesser effect on mast cells.
Our observations also point out the limited ability of analysis of the GST/glutathione pathway to predict response to chemotherapies like melphalan whose resistance is primarily mediated through a complex mechanism of detoxification.
