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DNA polymerase β primarily interacts with DNA through sequence independent interactions (sugar phosphate backbone and minor groove).
Overall, the critical parameter for protein blocking experiments is that blocking agent (e.g., casein) primarily interacts with the biosensing area instead of blocking the protein protein interactions observed in porcine skin gelatin experiments.
It was found that O2 primarily interacts with NH3 ad) on Brønsted acid sites.
In contrast, the Mg-ADP molecule in the consensus site primarily interacts with NBD2, and the consensus site is open (Fig. 4C and 4E).
While indole preferentially adsorbs on the NiMoS surface through the β-carbon of the pyrrolic ring (−ΔEa = 19 kcal mol−1), carbazole primarily interacts with the NiMoS surface through the phenyl rings (−ΔEa = 13 kcal mol−1).
In this study, we investigated the binding mode of four pyrrolyl DKAs to the HIV-1 IN active site by molecular modeling coupled with site-directed mutagenesis studies showing that the DKA pyrrolyl scaffold primarily interacts with the IN amino residues P145, Q146 and Q148.
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As intracellular [Ca2+] increases, cTnI reduces its binding interactions with actin to primarily interact with cTnC, thereby enabling contraction.
Given that macrophage scavenger receptors (e.g., CD36) contain hydrophobic residues near their oxLDL binding pockets, it is plausible that AMs primarily interact with scavenger receptors through hydrophobic interactions, resulting in reduced oxLDL uptake.
As downloadable applications have mushroomed over the last few years, publishers and app makers have questioned if consumers will primarily interact with media content on tablets and smartphones through downloadable apps.
HowAboutWe members fill out profiles consisting of photographs and factoids under headings like "One thing my mother would want you to know about me," but they primarily interact around the dates they propose.
One of these species is CO primarily interacting with coadsorbed hydrogen, the other is primarily interacting with molecularly adsorbed H2O.
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