The psychopharmacologic effects of nicotine are mediated primarily by functionally diverse neuronal nicotinic acetylcholine receptors (nAChRs), a family of ligand-gated ion channels widely distributed in the brain [9], [10], [11].
They have primarily been functionally related to leukocyte trafficking, but recent reports suggest their role in cancer development and progression as well (Strieter, 2001; Muller et al, 2001).
Some have been validated using deep sequencing, but many fewer have been validated functionally, primarily focused on non-synonymous coding SNPs (nsSNPs).
The content of these repositories is primarily derived from functionally known regulatory sequences, which are expected to be only a tiny fraction of all cis-elements.
This finding is compatible with the previous observations that hotspots are located primarily in highly conserved, functionally important regions of p53 [ 14, 17].
In higher plants, duplication of the ancestral bch gene took place most probably via whole-genome or segmental genome duplication [ 26] and the duplicates seem to have functionally diverged primarily at the gene expression level [ 60- 62].
Peripheral NK cells primarily fall into two major functionally distinct subsets.
Functionally, it acts primarily as a CNS depressant, potentiating the action of GABA at the GABAA receptor [ 10].
While both agents primarily affect a group of functionally related mRNAs, which are involved in cell growth and survival, EtOH and INK128 differentially affect the synthesis of distinct subsets of proteins involved in these processes.
Hence, the present work has been developed primarily with reference to such functionally relevant cross-reactivity, which is nonetheless of great interest from the standpoint of antibody-mediated immunity.
