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This latter observation suggests that the reduction in vasopressors is a consequence of the improved haemodynamic situation, therefore favouring the hypothesis of primarily eliminating a systemic vasodilating substance, such as NO.
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DTG is primarily eliminated through metabolism, and renal elimination of unchanged drug represents less than 1%% of the total dose administered.
Volasertib is primarily eliminated unchanged with metabolism representing a relatively minor elimination route as indicated by low exposures of the main metabolite (data not shown).
Metformin is primarily eliminated via the renal route through tubular secretion, with a plasma elimination half-life of 6.2 hours.
As VS is primarily eliminated through the liver into the bile and feces, patients with obstructive liver disease are more susceptible to its toxic effects, requiring a dose reduction depending upon the serum bilirubin concentration.
Methylnaltrexone is primarily eliminated as an unchanged drug (85% of the administered dose).
In dogs, topiramate is not extensively metabolized and is primarily eliminated unchanged in the urine.
Autoreactive T cells are primarily eliminated in the thymus by negative selection (central tolerance).
Linagliptin is primarily eliminated unchanged via the feces, by which 84.7% of an oral dose is eliminated.
Edoxaban is primarily eliminated unchanged through multiple pathways, with approximately 50%% of systemically absorbed drug eliminated via renal excretion.
Naltrexone is primarily eliminated by the liver with only 1% of an oral naltrexone dose excreted in urine [ 28].
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