Sentence examples for primarily defective from inspiring English sources

Here we find that IKKγΔ is primarily defective in IRF3 signaling, reducing type I IFN production and ISG signaling by displacing IKKγ-WT from MAVS complex with an isoform deficient in recruiting TANK-IKKε.

Published: June 18 , 2015We previously demonstrated that mutations in misato (mst) lead to frequent monopolar spindles (∼70%) with low microtubule (MT) density in Drosophila larval brains and that, upon MT regrowth after cold exposure, mst cells are primarily defective in kinetochore-driven MT generation [ 5].

Dsg 4 mutations are followed primarily by defective hair formation (Kljuic et al. 2003).

Historically, discussion of complementation among viral proteins has focused primarily on defective interfering particles.

Regardless of the exact pathway our model proposes that short RNAs (~21 nt in length) produced primarily from defective TMV RNA sequences are used to program the cellular RISC RNAA induced silencing complex) to target TMV RNAs for degradation.

To test whether the sterility caused by pans1 is due primarily to defective chromosome segregation during meiosis II, we crossed pans1 with (hemizygous) tardy asynchronous meiosis 1 (tand) and osd1 mutants in which the majority of meiocytes do not undergo the second meiotic division, leading to the formation of unreduced gametes [ 23– 25].

Once we have agreed that the existence of epistemic objects is established by the epistemic instruments (as for example the existence of the desk in front of me is established by my perceptual abilities, in this case primarily non-defective vision) we then have to address the further question of how to establish the instruments.

In chalcogenide glasses, semiconductivity is primarily caused by defective bonds in which a particular atom does not follow its covalent coordination.

However, we found that over-expression of Gng13 or Msln did not perturb T cell development from WT lymphoid progenitor cells in OP9-DL1 co-culture (data not shown), suggesting that increased expression of Gng13 or Msln is not primarily responsible for defective T cell development in tgε26+/+ mice.

Furthermore, our data underline that CCM pathology is primarily due to defective endothelial cells.

This disorder is primarily characterized by defective insulin secretion and action.