The unexpectedly large number of BMP-1/TLD-like protease genes (23) results primarily from expansion of a set encoding an unusual domain conserved in structure and primary sequence only in nematode astacins.
Work in multiple organisms has demonstrated that pRb complex members play a primarily repressive role in transcription, a function that is also conserved in C. elegans (Chi and Reinke 2006; Kirienko and Fay 2007).
However, as the protein sequence in this region is conserved in all chordopoxviruses with only minor amino acid differences (seen primarily in the avipoxviruses and molluscum contagiosum virus), it may play a significant functional role.
Mammals are heavily reliant on hearing for a variety of ecologically important roles (Macdonald 2009) and it is likely that evolution has acted primarily to conserve the function of hearing genes, many of which are functionally conserved in tetrapods.
The substitution appears to proceed primarily through overall double inversion, with the absolute stereochemistry of the starting material being conserved in the product.
First, EF-1α's binding sites for aa-tRNAs, GTP, and its nucleotide exchange factor EF-1β are conserved in EFL: evolutionary rate shifts and divergence without rate shifts are confined primarily to non-binding sites.
Two interfaces, located primarily on EC2-EC3, involve distinctive clustered Pcdh structure and sequence motifs, lack predicted glycosylation sites, and contain residues highly conserved in orthologs but not paralogs, pointing toward their biological significance as homophilic interaction interfaces.
This composition is conserved in vertebrates.
LATS1/2 proteins share LATS conserved domain 1 (LCD1) and LATS conserved domain 2 (LCD2), which are conserved in all vertebrate LATS1/2 homologues.
She's flawlessly conserved in the cool current.
