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Upon mutation, its intrinsic GTPase activity is lost and GAPs are unable to bind RAS resulting in RAS primarily bound to GTP and therefore constitutively activated [16].
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a macrophage-synthesized lipase that is primarily bound to small electronegative low-density lipoproteins (LDLs).
Selectively adsorbed ions are assumed to form inner sphere complexes with surface hydroxide sites that is, they are primarily bound to the surface of clay minerals by chemical bond.
This has transformed Korea from a traditional patriarchal society, where women's roles were primarily bound to the household, to a modern industrialized society, where women's rights and roles in society are important for quality of life.
Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzymatic inflammatory biomarker primarily bound to low-density lipoprotein cholesterol, is associated with an approximate twofold increased risk of cardiovascular disease and stroke.
Because RCC1 is restricted to the nucleus whereas RanGAP is excluded from this compartment, Ran is primarily bound to GTP in the nucleus and to GDP in the cytosol – an asymmetric distribution critical for the directionality of nuclear transport [10].
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UDP-GalNAC primarily binds to the C-lobe and is surrounded by four conserved residues (i.e., His109, Lys192, Glu256 and Glu264).
"The data in this paper clearly demonstrates that sperm primarily bind to a specific sugar molecule... present on the outer surface of the egg," Clark says.
In the competition experiments with ibuprofen probes and warfarin probes for HSA binding sites, Bari et al. demonstrated that quercetin primarily binds to the site located in the subdomain IIA [146].
Cadmium ions bind with anionic groups which primarily bind to metallothionein and albumin.
This suggests that microRNAs primarily bind to canonical sites to control protein production.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com