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On average, the compounds inhibited 39 kinases, with four structures inhibiting more than 183 kinases (μ + 3SD), namely the known pan-kinase inhibitor Staurosporine (at 1 μM and 10 μM), a compound primarily annotated as a Cdk1/2 inhibitor, the structure K-252a and a PKR inhibitor (10 μM).
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Contigs were annotated as above.
All sequences were annotated as above.
Each sample was measured on two plates: A and B; plate A consisted primarily of miRNAs that are annotated as miRNAs in miRBase (http://www.mirbase.org/), whereas plate B consisted primarily of star sequences.
It is noteworthy that PPI data in HPRD were annotated as common to all protein isoforms, primarily because of the general lack of experimental data [ 13].
Out of the 46 targets, 26 are annotated by the Census as oncogenes in the reported cancer type, 19 are annotated as tumour suppressors28, and one — CBL, encoding an E3 ubiquitin protein ligase — is annotated as having both functions.
Some names were crossed out with Vietnam dates; some were annotated as natural-cause eliminations.
As shown in Fig. 3B, 60% of them are classically annotated as secreted proteins.
TSSs located intergenic region without cognate gene were annotated as orphan (o).
Immune clusters for tumour regions without RNA-seq data are annotated as grey.
Similar observations can be made for all other genes annotated as having non-random RNA localization.
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