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As previously reported, affected members in Family 1 carried the homozygous M128V-V393A varinnt in COQ2 and those in Family 12 carried the compound heterozygous R387X/V393A variants in COQ2.
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This is reminiscent of the previously reported affects of OGT and OGA null mutants on UV stress tolerance [ 7].
Since the beginning of the new century, the AIDS epidemic in Brazil has reached new population groups and cities where it had not been previously reported, affecting the less privileged social segments in the country [ 3, 21, 23].
Given the limited existing ERP data on AD-ADHD, this study aimed to provide a detailed investigation of key ERP indices, previously reported as affected in childhood ADHD, in adults with ADHD, to investigate possible developmental stability in the associated deficits.
In combination with est1 ∆, we tested the effects of deleting 27 genes previously reported as affecting telomere length (Askree et al. 2004; Gatbonton et al. 2006; Shachar et al. 2008), 15 affecting DNA replication and repair (Collins et al. 2007), and 18 other genes that were randomly chosen controls or of some prior interest (Table S1).
Polymorphisms in eba140 and eba181 previously reported to affect specificity of erythrocyte binding in a transfected COS cell assay [45], [46] were tested but not associated with severe malaria here.
As a first step to interrogating the genetic basis of withdrawal behaviour in C. elegans we investigated whether mutants previously reported to affect ethanol dependent behaviours altered responses in the food race paradigm.
From each confirmed type 2 diabetes risk locus previously reported to affect specific aspects of β-cell function, we selected one representative SNP based on the availability of genotype data and on the robustness of the SNP's β-cell effect in our cohort.
All three variables have been previously reported to affect survival.
Modulation on IFN-γ production has previously reported to affect NK cell cytotoxicity [ 21].
A causative mutation in the ABCG2 gene was previously reported to affect milk yield and composition in dairy cattle [ 34].
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