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Consequently, HSP90 inhibitors plus trastuzumab have significant anticancer activity in patients with HER2-positive, metastatic breast cancer previously progressing on trastuzumab[ 17].
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Two patients receiving cisplatin gemcitabine achieved disease stabilisation having previously progressed, the remainder had disease progression.
* Had never previously progressed beyond the third round at Wimbledon.
According to Mr. Fiddler, a rapid evolution for machines that previously progressed at glacial speed is now possible, thanks to advances in embedded chips and software.
Neither Costa nor Johansson had previously progressed beyond the quarter-finals in any of the grand slam tournaments, and both lifted the winner's trophy with more than a touch of genuine bewilderment.
But Johansson, who had never previously progressed beyond the last 32 in Melbourne in seven attempts, overcame first-set nerves to perform with immense resolution, interwoven with moments of considerable panache.
With the reassurance of a settled place in Chelsea's starting line-up the German's class has become apparent and last night he found the perfect stage to express it against an Olympiakos side surely as weak as any that has previously progressed this far in the competition.
While it is one of the richest clubs in France and is chasing a national championship — it stands second and is sure of a place in the title playoffs — it has never previously progressed beyond the quarterfinal of the European competition.
The two sides, who have won the competition four times previously, progressed following wins over Wolves and Newcastle respectively.
Korea, convincingly beaten by tournament favourites Brazil in the last four, had never previously progressed past the Olympics quarter-finals and their victory in the Millennium Stadium was greeted by joyous celebrations at the final whistle.
He has three brothers, all of whom play football, including Thorgan, who joined him at Chelsea in 2012 and had previously progressed through the youth ranks of Lille's biggest rivals Lens.
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