We describe cell fate choice of MPCs with temporally regulated depletion of ntla function, previously requiring technically more challenging cell transplant experiments.
CMAPi generates the most accurate interface alignments for cytokine families, one of the more challenging cases previously investigated by LTHREADER.
Because different PAHs act on fish embryos via independent toxic mechanisms, understanding the cumulative toxicity of PAH mixtures will be more challenging than previously appreciated.
In our opinion, this amply demonstrates that homologization attempts at the level of SL-ir neuron types is anything but straightforward outside of the tetraconates, and even in the latter taxon more challenging than previously assumed [ 26, 62].
While many solid tumours appear to be driven by T-ISCs, emerging data suggest that phenotypically distinct subsets exist within T-ISC populations (Meyer et al, 2010; Patel et al, 2012; Visvader & Lindeman, 2012) and thus targeting of this population therapeutically may prove more challenging than previously appreciated.
John Lawson at Investec said: The UK parcels sector seems to be going through a more challenging period than previously anticipated, as UK Mail has not seen the normal seasonal pick-up at the rate expected.
The retailer on Wednesday lowered its annual profit forecast after reporting a 13 percent drop in second-quarter profit, as its expansion into Canada — its first foray outside the United States — has proved more challenging than it previously thought.
In the Bavarian town of Lindau, where 18 Nobel-winning economists gathered last week along with 450 graduate economics students from around the world, the atmosphere was a little more challenging and the previously meek response of those who criticise conventional thinking had grown louder and more coherent.
Complex traits are proving to be much more challenging and frustrating than previously thought.
Recent work in the field of vaccines, however, indicates that vaccines may be developed for even more challenging diseases than those previously addressed.
This type of clinical work was far more challenging than anything I had encountered previously.
