Moreover, a changing patient demographic would likely have an impact on enrolment and programme adherence rates, and subsequently mortality, although the latter has not been previously investigated to our knowledge.
However, their application to the evaluation of diagnostic accuracy has not, to our knowledge, been previously investigated.
Bias and precision when assessing posture percentiles have not to our knowledge, been previously investigated, nor have the effects of the selected sampling strategy on the size and structure of these errors been quantified.
The relative importance of these different sources and possible interaction mechanisms for vitamin D status in primary health care at more northerly higher latitudes has not to our knowledge, been previously investigated.
We also examined these associations in both early and late adolescence and by gender and social class, the latter of which has not, to our knowledge, been previously investigated.
Our hypothesis, to our knowledge not previously investigated, was that radial angulation may not be the primary determinant for the child's activity and participation, nor for the self-rated opinion of appearance.
The cause of the ROS defect within CGD2 cells has not, to our knowledge, been previously investigated, so we took advantage of the isogenic properties of clones C4 and E4, which are genetically and phenotypically WT at the CYBB locus but within the genetic background of CGD2 cells, and we measured the levels of CYBB mRNA and protein in monocytes.
The phospho-CDC25C (Ser 216) has to our knowledge not been previously investigated in any human cancer.
Also of concern, increasing rates of infections due to antimicrobial resistant pneumococcal serotypes not-included into the heptavalent PCV have been reported [ 3- 6] To the best of our knowledge two surveys previously investigated physicians' self-reported attitudes toward the management of young children presenting with a fever without a source, since the introduction of PCV [ 7, 8].
To the best of authors' knowledge no study has previously investigated the association of self-reported anxiety and depression with NH.
