That part (above) isn't new – it was previously available in the initial SaneBox offering.
The protein sequences with similarity above the cut-off that were not previously included in the initial clusters were added to their corresponding best-scoring initial clusters.
In turn, we randomly labeled up to 70% more proteins as orthologs in C. elegans than were previously present in the initial set.
At the end of the protocol, all dogs were anaesthetized and ventilated mechanically as previously mentioned in the initial surgery to evaluate hemodynamic parameters.
Confirmatory factor analysis (CFA) was used to confirm the factor structure of the underlying dimensions of the construct that were previously identified in the initial psychometric testing of the QPCQ [ 28].
A further late test set of 49 samples (26 normal and 23 RCC, including 8 controls and 6 RCC samples previously run in the initial set, to check the longer-term reproducibility) was analysed by SELDI 6 months later.
A comparison of these numbers with the predictions previously obtained in the initial paper describing our method, in which we used the UniprotKB (update 2012_02) from February 2012 [ 27], illustrates the increase in the number of predictions between these two versions in just twenty months, totaling an increment of more than 61% from the approximately 17400 predictions obtained at that time.
We used the subpopulation treatment effect pattern plot (STEPP) methodology [ 24] to graphically explore the effect of the treatment on the change in ki-67 considering increasing values of the biomarkers considered, as previously described in the initial study finding [ 9].
In a subset of patients, subsequent muscle damage from a variety of potential causes (such as viral infection, trauma, toxin exposure) may lead to muscle damage and regeneration, and may reactivate immune responses previously generated in the initial anti-tumor response.
It is important to note, as previously mentioned, that in the initial studies we assumed that all vehicles in the simulation are equipped with the technology for message propagation.
