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While further studies should be certainly conducted to increase our understanding on the dose-response of HS, molecular findings suggest that the biochemical response to humic treatments may principally depend on a transcriptional mechanism of regulation, as previously hypothesized for the regulation of a maize isoform of H+-ATPase [34] and with a more holistic approach by Trevisan et al. [46].
Since βHB did not extend lifespan in eat-2 pharyngeal pumping mutants, βHB likely acts as a dietary restriction mimetic, as previously hypothesized for its effects in mammals [ 71].
Our combined results suggest a complex polygenic architecture underlying migration-related traits in this species, as previously hypothesized for migration (Dingle 1991), and provide the foundation for understanding the genetic mechanisms underlying smoltification and migration-related traits within this species and across taxa.
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Motor recovery induced by transplanted cells appears thus to be indirect and is likely due to activation of endogenous preserved circuitry via trophic support supply and/or generation of favorable substrate for axonal growth as previously hypothesized ([27], (for reviews see [7], [28]).
In the previously hypothesized structure for the diss. 1 aptamer,[ 12] this G-to-A transition might replace a G T wobble with an A T pair.
The reviewers were also concerned about the illusory contour figure: At present, the connections between higher-order correlations and previously hypothesized roles for V2 seem tenuous and insufficiently detailed to warrant a full figure in the main text.
This argues against a hindered dNTP closing for this enzyme previously hypothesized to account for its altered fidelity (22).
In fact, a comparison between the pea aphid genome and that of its symbiont [ 10, 28] confirmed the previously hypothesized integrated metabolism for these two organisms, in particular for the amino acid pathways [ 23, 29, 30].
One alternative portal from our simulation result agrees well with the previously hypothesized alternative portal for LFABP.
A similar pattern of force x repetition interaction might be evident in adaptative/repair or degradative responses, which may be superimposed with inflammation, with continued performance of repetitive tasks, according to a previously hypothesized tissue tolerance model for MSDs [ 41] and tissue adaptation hypotheses [ 52, 53].
Zand et al [ 41] have previously hypothesized a similar mechanism for generation of CD4 T cell memory, and Ganusov [ 42] hypothesized a similar mechanism for generation of memory CD8+ T cells in vivo during lymphocytic choriomeningitis virus infection.
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