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It has been reported that previous vaccination of children with trivalent vaccine of the last four seasons i.e. 2005 2006 to 2008 2009, did not elicit a cross-reactive antibody response to the pandemic H1N1 strain [4].
At low baseline probabilities of attack and exposure, mass previous vaccination of a metropolitan population is more costly ($815 million for a city of 5 million people) and not more effective than no vaccination.
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Although there were some trends based on vaccination history over the last 5-year period neither in the younger nor the aged did the effect of previous vaccination on responsiveness reach significance.
Grazing at communal pasture increased odds, but usage of disinfectants, previous vaccination for brucellosis, and tap water were protective.
Additional analyses were conducted to evaluate a scenario considering a 3 doses vaccine course (previous vaccination schedule) and inclusion of head and neck cancers and sick days lost based on reported data for Germany [5].
Pre-existing immunity to YF virus was defined as self-reported vaccination within the 10 years before the current clinic visit; evidence of previous vaccination usually involved presentation of a YF vaccination certificate, but no serologic tests were performed to confirm immunity.
Secondary objectives were to determine the effect of previous vaccination with seasonal influenza vaccine on the risk of hospitalization with pH1N1, and to identify risk factors for hospitalization with pH1N1 or acute respiratory infection (ARI).
Previous vaccination or history of prior influenza infections were not included in the model and could similarly affect infection dynamics and exposure probabilities across the different simulations.
Finally, the study did not have sufficient statistical power to evaluate immune responses according to age strata or by previous vaccination history, both of which are known to influence immunogenicity.
(Table 1) A third (33.4%) of the women had a negative vaccination history (no history of previous vaccination or unknown vaccination status); nevertheless, 81.4% of them were immune to rubella.
During supplementary immunization activities (SIAs - or mass immunization campaigns) oral polio vaccine is offered to all children under five years of age, irrespective of previous vaccination status.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com