The study confirms the results of two previous trials in South Africa, and Dr. Gray believes that taken together the studies have significant implications for public health.
The government has promoted trials of retired military officers; unlike previous trials in the 1980s, which ended in an amnesty after threats of military coups, these ones have not included any guerrilla leaders.
Mr. Schwarz also faces two perjury counts asserting that he made false statements at one of his two previous trials in denying that he led Mr. Louima to a stationhouse bathroom and in denying that he was present during the attack in the bathroom.
The TTM-trial differs from previous trials in several aspects, the most important one being that all patients received controlled temperature management avoiding fever in both intervention arms (Fig. 6).
In this article, we consider lessons learned from previous trials in mRCC and discuss how these lessons might be implemented in the design of future trials that focus on clinically useful questions and provide results that can be readily interpreted.
Previous trials in chronic migraine with topiramate for 4 months have shown a reduction in headache days per month of 3.5 and 6.4 days in the verum group, which exceeded the effect in the placebo group by 3.7 and 1.7 days, respectively [6, 30].
The RTS,S/AS02D reactogenicity profile was similar to that recorded in previous trials in older age groups [2], [5].
Our study confirms the results of previous trials in Asia [8] and Africa [10] [13] that found DHA-PQP to be as effective as other ACTs, including AL.
The prevalence of PfDHFR triple mutation was lower in this study than in children who received IPT with SP+AQ or SP+AS in the two previous trials in the same area [3], [4].
In the current study a small number of items or features form a large number of associations by permutations and thus participants have to 'forget' associations learned in previous trials in order to perform well on the current one.
This study and previous trials in adults and children showed that the AS01 formulated RTS,S vaccine induces higher anti-CSP antibody responses than the AS02 formulation [5], [22], [32], [33].
