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Two thirds of women in the GZ cohort had a previous termination of pregnancy or miscarriage (69%), while one third was observed in the HK cohort (34%).
A subgroup analysis in gestational age at delivery categories showed that previous termination of pregnancy had the strongest association with preterm delivery at early gestational ages (table 3).
Information on whether there had been a previous termination of pregnancy or not was registered based on responses given by the pregnant woman in a predefined pregnancy intake questionnaire, among others on reproductive history.
In two-thirds of the women registered in the (legally required) abortion registry, it was the first termination, one quarter had one previous termination and the remaining group had two or more previous terminations.
Another factor to consider is the fact that she had a previous termination of pregnancy in the first trimester via suction curettage previously to this pregnancy in 2012 that could cause a defect in the uterus.
Another limitation could be that we did not correct for other potential risk factors as previous preterm delivery, since we did not have such data, and previous termination of pregnancy in these women since this potential confounder was only recently established [ 36].
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The mean number of previous pregnancies was 1.3 (+/- 1.5), and the rate of previous terminations 1.7%.
Previous reports showed that stimulation with limited antigen dose and premature termination of TCR signaling promotes generation of Treg cells [43], [44].
In a previous study, silencing MYB305-like genes in N. attenuata results in premature termination of flower development [ 42].
A previous pregnancy termination was reported in 16 000 (1.2%) deliveries.
A detailed obstetric history was recorded including previous miscarriage, termination or perinatal death.
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