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A structural comparison of these complexes, with the previous structure of the NPR-C/CNP complex, reveals that NPR-C uses a conformationally inflexible surface to bind three different, highly flexible, NP ligands.
The previous structure had two-by-fours placed six feet apart, Mr. Hayes said.
"Whatever you think of the previous structure, it's just being corrected big time.
The European commission is still investigating the tax benefits Amazon may have gained from its previous structure.
Walls have been erected and appear to be even taller than the previous structure, and a roof has been added.
"This marks a return to our previous structure of managing primary and secondary markets as a single business line," Mr. Gulliver and Mr. Studzinski said in the memo.
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Previous structure-based design studies resulted in the discovery of alkyl substituted diphenyl ether inhibitors of InhA, the enoyl reductase from Mycobacterium tuberculosis.
However, previous structure-activity relationship studies have heavily investigated the macrocycle region of largazole, while there have been only limited efforts to probe the effect of various zinc-binding groups (ZBGs) on HDAC inhibition.
Our previous structure-activity relationship studies revealed that these analogs would have the same mechanism of action [8].
Previous structure-function studies of the endophilin-A BAR domain have almost exclusively been made in reduced systems, either in vitro or ex vivo in cultured cells.
Our previous structure-activity studies identified several promising OSCs (F, H, K, L, N, O, P and Q).
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