Previous studies with short recall periods have suggested that informed administration (previous responses available) may improve the responsiveness and validity of health-related quality-of-life (HRQL) questionnaires in comparison to blind administration (previous responses unavailable).
We also compared previous threat-responsiveness related behaviors (prior vaccinations and previous visits to physicians for flu-like respiratory conditions) of those who received vaccination and those who did not (Additional file 1).
A previous study about responsiveness for the WOMAC and SF-36 after THR also reported good responsiveness on the WOMAC subscales and the physical domains on the SF-36 [ 11].
As expected from previous work, CO2 responsiveness was preserved under sevoflurane anesthesia in the present study.
The client exit interviews had a mix of closed and open ended items to explore client experience in the clinic related to service supply and responsiveness, previous experiences, opinions about the NHIS, and suggestions for making the NHIS more responsive.
As one part of a conserved DNA module involved in light responsiveness, previous studies showed that the Box 4 element is frequently found in promoter regions of different genes from various species [ 51, 52].
Although there were some trends based on vaccination history over the last 5-year period neither in the younger nor the aged did the effect of previous vaccination on responsiveness reach significance.
Previous studies on responsiveness have focused mainly on the evaluation of the entire health systems within or amongst different countries [ 3, 9, 10, 12, 32] but our analysis concurs with other studies [ 11, 49] in suggesting that the responsiveness concept can also be applied in specific parts of the health system.
The significant difference between groups of 1.4 points in the current study does, however, equal the optimum threshold for improvements for performance scores reported in a previous study of responsiveness of the COPM [ 27], and has also been used as an estimate of a clinically relevant difference in another trial [ 28].
Moreover, the addition of soluble MD2 to HEK-TLR4 cells was absolutely required for LPS responsiveness, confirming previous reports [27] [29], whereas PLN induced similar cytokine release by these cells in the absence or presence of soluble MD2 (data not shown).
