Our results confirm previous observations concerning preferential motor reinnervation for motor neurons, and show for the first time anatomical evidence of specificity during regeneration of sensory afferent projections to muscle.
Based on previous experiments using preferential looking, we predict that when presenting a resynthesised growl to a domestic dog that is within visual range of two differently sized dog models, the subject will look at the size-matched model more often and for a longer duration than at the unmatched alternative.
While reporting an increase in overall quadriceps activity, none of the previous studies demonstrated preferential recruitment of the VMO.
This should be of additional importance when one considers the previous demonstration of preferential localization of CB1R in situ to the astrocytic end-foot (Rodriguez et al., 2001).
This is unlike previous studies showing preferential localization of antisense transcripts in the upstream and downstream regions of the gene [ 53- 55].
Our results do not contradict previous reports of preferential co-location of sites among homologues, but rather point at the importance of not ignoring other sites, especially in large and diverse superfamilies.
For instance, a previous study reported preferential recombination at GC clusters on the mitochondrial genome (Dieckmann and Gandy 1987); however, we did not detect any hotspot enrichment in these regions.
While our results corroborate previous work demonstrating preferential post-polyploidization transcript absence for homoeoloci on the D genome [ 70, 72], it is nonetheless particularly unexpected given that the D genome was integrated into hexaploid wheat only ~8,500 years ago.
This is consistent with our previous observations demonstrating preferential infection of the stomach in this model (Vautier et al., 2012) and the fact that that colonization is restricted to the lumen elsewhere in the GI tract (discussed above).
