In contrast, previous localisation studies using HeLa cervical cancer cells (L-132) showed that, upon induction with IFN- γ, LMP2 was highly enriched in the cytosol while nuclear staining was negligible (Brooks et al, 2000).
Despite the controversy about whether a basement membrane surrounds islets of Langerhans, the previous localisation of collagen type IV [ 6] suggested that the matrix around islets was a basement membrane.
In accordance with previous in vivo studies, localisation was not affected by glucose concentration (data not shown) [ 15].
Surprisingly, unlike the results of a previous preliminary analysis, the localisation of the catheter tip did not influence the prevalence of detected methylation.
Age, sex, hypertension, smoking, diabetes, coronary artery disease (CAD), previous MI, high cholesterol, localisation of MI were tested (through univariate analysis) for association with hospital mortality.
Surprisingly, in C. roseus cells, CrSGD-GFP perfectly colocalised with the nucleus marker and was clearly excluded from the ER contradicting the previous proposed CrSGD ER localisation [ 1].
A multivariate analysis by the Cox proportional hazard model confirmed that previous PFS and pancreatic localisation were significantly predictive of survival (Table 5).
Our previous study investigating the localisation of these growth factor receptors, demonstrated expression of TGF RII, FGF R3 and IGF RI in the endothelial cells of blood vessels, as well as the native IVD cells.
Three previous studies identified nuclear localisation of CXCR4 in hepatocellular carcinoma (Shibuta et al, 2002), invasive ductal mammary carcinoma (Kato et al, 2003), and non-small-cell lung cancer (NSCLC) (Spano et al, 2004).
Consistent with the results in the previous reports about HuR localisation in normal and malignant cells, HuR was expressed only in the nucleus of HMVECs; however, it was also expressed in the cytoplasm and nucleus of malignant melanoma and oral carcinoma cells.
For classifying TKA patients, symptoms took precedence, followed by radiological evidence, mobility, age, previous surgical management, and localisation [ 58]. 'Appropriate' TKA referral patients saw greater gains in the social function score and the three WOMAC dimensions than 'inappropriate' patients [ 57, 59].
