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Several genomic regions identified in this study, mostly in the varietal group-specific GWAS, were discovered in previous linkage mapping studies.
Previous linkage analyses in migraine families have shown association between several loci and MA and MO with LOD > 3 [19–25].
After 4 rounds of backcrosses with CJ06, the BC4F1 and BC4F2 generations were scanned with a set of 71 SSR markers, which were uniformly distributed on a previous linkage map (Additional file 1: Table S4).
A simple genetic architecture was revealed for frost tolerance in this population, with a principal role for the Fr-H1/Vrn-H1 and Fr-H2 loci already detected in previous linkage and association mapping studies.
Several previous linkage and association studies and an expression analysis have suggested the gamma-aminobutyric acid type A receptor beta3 subunit (GABRB3) gene as an important candidate gene for autism.
Previous linkage and association studies identified an approximately 30 kb region associated with prostate cancer risk.
Following their work, Roeder et al. [43] proposed formulating weights based on previous linkage traces.
In all, 5 previous linkage studies have implicated QTLs on 12 different chromosomes [5], [7], [8], [9], [10].
A few of them were spread to cover the remainder of the LOD score profile in our previous linkage studies.
Our GWA scans also found several novel QTLs that do not overlap with previous linkage analysis regions (Figure S6).
In our previous linkage studies for HD, we used 3 HD phenotypes including the NA and their PCs.
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