Worse treatment response in patients with more previous mixed episodes, delusions during manic episodes, and appetite increase during depressive episodes was observed not only in the main analysis of all subjects but also in the supplementary analysis of BD-I patients alone.
In previous studies, hallucinations and delusions were usually combined and categorized under the broad category of psychosis [ 16], and the largest of these studies have shown no association between APOE*4 and a broad category of psychosis [ 5, 17].
Based on a previous principal component analysis, psychosis (delusions, hallucination), agitation (agitation/aggression, disinhibition, irritability) and affective (depression, anxiety) sub-syndrome scores were formed by summing the score of the included items [ 50- 53].
His previous book, "The God Delusion," a furious howl of rage against organized religion, was an international best seller and made Mr. Dawkins, unofficially, Britain's Top Public Atheist.
Previous studies have shown paranoid delusions to be significantly related to poor ToM performance, in both first and second order ToM tasks and in both verbal and pictorial paradigms [[ 27, 28] 32].
However, Peters et al 18 reported higher prevalence rates than those shown in previous studies, except for elation and delusions.
The patient had a previous psychiatric history of depression and delusions 3 years before but the diagnosis of bipolar disorder was not evoked.
This nurse-led interview included ten items probing for delusions and hallucinations over the previous month.
A protocol-specified analysis of individual NPI items (not reported here) showed a significant advantage for memantine over placebo on agitation/aggression, irritability/lability, nighttime behavior, and delusions, which is consistent with previous studies [ 10, 29– 31].
Eligibility depended on the presence of persistent delusions or auditory hallucinations during the previous three months before consent was obtained.
