In our studies, both SO and SOAE pre-treatment significantly reduced the LOX1 expression in aortic lesions, suggesting its role in preventing the internalization of Ox-LDL followed by inflammation initiation, an early event which leads to a cascade of actions in disease progression.
The chemically anchored PEG chains can undergo spatial conformations, thus preventing the internalization of NPs by the cells.
N-cadherin and cadherin-11 both have recently been identified to interact with the FGF signaling pathway by binding to FGFRs and sustaining the FGF signal by preventing the internalization of the FGFR [ 15, 36].
Talking and communicating as a family may prevent the internalization that's too often a part of the intergenerational transmission of mental illness.
The binding of hepcidin to ferroportin induces its internalization and degradation in the cytosol, which prevents the release of intracellular iron [ 13].
It thus prevents the use of fluorescent markers, such as Rhodamine, Cyanine-5 or BoDIPYs, which may influence the internalization and localization of NPs in the cells (Miladi et al. 2014).
During bacterial infection, inflammatory cytokines, such as IL-6, prompt the liver to increase the production of the iron metabolism regulatory peptide hepcidin, causing the internalization of ferroportin and thus preventing cellular iron export [ 82, 84].
This phosphorylation results in either the internalization of the GPCR or arrestin linking, which prevents G protein binding.
As LPS is crucial for the internalization of Salmonella [22], blocking the interaction between LPS and host cells may prevent subsequent tissue invasion.
In contrast with the internalization of L5, that of V5 was sensitive to the blockade effect of RAP, which also prevented endocytosis of V1 V4.
