Exact(2)
A 44-residue deletion in the ectodomain prevents attainment of the native structure and results in degradation from the ER lumen when the proteins are ectopically expressed in cultured cells.
The crucial new feature that sustains oscillations is linkage of Nrf2 nuclear import and export by the PGAM5-mediated feedback loop which prevents attainment of the equilibrium steady-state with different phosphorylation steps driving Nrf2 relocation.
Similar(56)
However, the presence of intrinsic components, such as nucleases in the cell-extract-based cell-free protein synthesis system, reduces the stability of the ternary complex, which would prevent attainment of reliable results.
We demonstrate the usefulness of our method for assessing critical concentrations of external metabolites preventing attainment of a metabolic steady state.
A major limitation to inpatient use of oral antidiabetic agents relates to the delay in and unpredictable onset of action, which prevents rapid attainment of glycemic control or dose adjustments to meet the changing needs of the acutely ill patient.
As described in accumulation-of-evidence models of decision making (Shadlen and Kiani, 2011), a failure to attain a threshold-level activation at one of these stages cuts the process short, prevents the attainment of a conscious-level representation, and causes the information to linger and decay.
8 13 Influencing directly or indirectly on bone metabolism, alcohol consumption during adolescence and young adulthood, before the mid-30s, prevents the attainment of optimal peak bone mass (PBM), which is a major contributor to the development of strong and healthy bones in later years.
It is uncertain whether wild birds hatched in the spring actually do breed during the summer; environmental control factors, especially decreasing day length, probably prevent the attainment of breeding condition by two-month-old birds in natural situations.
However, large values of κ and a sharp reduction in the S at high temperature due to bipolar conduction prevent the attainment of high thermoelectric figure of merit.
However, in 1956, Gabaldón insisted that "nothing except the lack of funds should prevent the attainment of [a malaria-free Venezuela]" (29 ).
Unskilled birth attendance is a major obstacle preventing the attainment of MDG 5 which seeks to reduce maternal mortality in LMICs [ 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com