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The position of var loci in heterochromatic perinuclear clusters prevents accessibility to specific and general transcription factors and this is probably the most important determinant of transcriptional inactivity (Freitas-Junior et al., 2000; 2005; Duraisingh et al., 2005; Ralph et al., 2005; Voss et al., 2006; Flueck et al., 2009; Lopez-Rubio et al., 2009; Perez-Toledo et al., 2009).
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Indeed the many barriers in the fixed-route prevent accessibility for this service.
Besides, detergents were found to form a protective layer on lipase substrate and in turn prevented accessibility of lipase towards substrates (Yao et al. 2013).
Of course, the whole point of private insurance is to prevent accessibility and affordability.
This competency is reduced at intergenic regions by sequence features, barrier nucleosomes, and proteins, preventing accessibility regulation of untargeted genes.
Arrays of well-positioned nucleosomes may arrest nucleosome remodeling at gene boundaries and hence prevent accessibility regulation of neighboring genes.
This might be due to the steric hindrance caused by bulky hydrophobic TMG moieties, which might have prevented accessibility for protonation of the TP polymers [ 19, 28].
Special features of the 5′UTR could include self-bending of the 5′UTR preventing accessibility to the RBS, thus requiring specific sRNAs to prevent bending/looping and thus allow translation [ 41].
However, there is still a question of how ligninases secreted by P. chrysosporium can selectively access these regions, since the compact structure of the cell wall rigidly prevents enzyme accessibility.
This prevents the accessibility of Pd to the gaseous reactants.
It also prevented the accessibility of the water to the tube materials and consequently local, prolong, overheating took place, in which the temperature rose up to 700°C in a frequent manner for long time.
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CEO of Professional Science Editing for Scientists @ prosciediting.com