In the preventive experiment, J. montana co-administered with a high fat diet significantly inhibited body weight gain, blood glucose, triglyceride, total cholesterol, LDL-C, vLDL-C, HDL-C, fattyfacid andd atherogenicenindexdex levels in a dose dependent manner.
In the preventive experiment, the mice survival time was significantly longer in the vaccine group than in the control groups (P < 0.05).
For the preventive experiment, CIA mice were given intraperitoneal injections of phosphate-buffered saline (PBS), Fc, VEGF-Trap, Tie2-Fc or DAAP (25 mg/kg, twice weekly) from day 21 to day 40.
In preventive and therapeutic experiments, G22-I50 could reduce tumor size and prolong the survival time of HNE2-bearing mice (p < 0.05).
In the preventive and therapeutic experiments, however, the differences between pcDNA3.1-VNTR, pcDNA3.1 and PBS groups challenged with panc02-MUC1 are large, as discussed below.
In both the preventive and therapeutic experiments, the tumor size was significantly less in the vaccine group than in the control groups (P < 0.05).
As observed in the preventive set of experiments, this data show that in the therapeutic treatment period, the clearance effect of the EB101 vaccine on A β plaques per section was about 59% compared to controls.
In the spontaneous ankylosing enthesitis model, systemic over-expression of noggin, a BMP antagonist with broad ligand affinity, inhibited the incidence, and clinical and histomorphological severity of arthritis in a dose-dependent manner in both preventive and therapeutic experiments [ 20].
In addition, the serum concentration of anti-CII IgG1, IgG2a and IgG2b in the CCX8037-treated group was not lower than the vehicle group both in the preventive and therapeutic treatment experiments (data not shown).
