The abuse-prevention rationale faces distinctive challenges.
The anti-harming rationale for restricting liberty is narrower than the harm-prevention rationale.
Only the broader harm-prevention rationale would explain how Mill could hope to square Good Samaritan laws and laws compelling testimony in court with the harm principle.
Another challenge for the abuse-prevention rationale is that it is difficult to ground either in a consequentialist or in a deontological ethics.
Alternatively, if it is correct for such studies to not always require informed consent, this calls the abusive conduct-prevention rationale into question.
It is also the rationale for what Bentham later called the "disappointment-prevention principle" (1838 43, V, 416), which requires that the security of legitimate expectations take precedence over other ends, save where the public interest manifestly justifies government intervention.
The paper describes the theoretical foundation for EARLY ALLIANCE, the goals of the prevention trial, the rationale for design choices, and the methods employed.
Disease prevention was another rationale for assessing the effect of antibiotics on the endosymbiotic bacteria and, indirectly, on the ticks themselves.
The economic rationale for prevention needs to be kept up-to-date as relevant disease patterns, risk factors and expenditure patterns change through time.
If the former hypothesis will be proved, trials of PFO closure for migraine prevention would have a rationale, in the latter case there will be no reason to close the PFO to prevent migraine.
Rationale: The prevention of AKI using sodium bicarbonate has been performed in a randomized controlled multicentre study (sodium bicarbonate vs 0.9%% sodium chloride) with a primary endpoint being the occurrence of AKI in the post-operative period [156].
